Macromolecules Mimicking Backbones of Nucleic and Teichoic Acids.Synthesis,Some Properties and Applications

1 Results Several methods have been elaborated in this laboratory allowing preparation of macromolecules with phosphodiester bonds,and having sequence of atoms similar as in the chains of biomacromolecules - nucleic or teichoic acids (TA),namely:-(C)n-O-PO-,where n=2 (for teichoic acids) or 3.These methods,to be discussed in the lecture,are based on the ring-opening polymerization,transesterification,and recently elaborated direct addition of phosphoric acid to diepoxides.For the first time an attempt has been made to directly reacting phosphoric acid with diols in the presence and absence of catalysts.The major side reaction,preventing high molar mass polymers formation,results from dealkylation,i.e.nucleophilic attack of the OH groups on the C atom,instead attack on the P atom.The other two methods allowed reaching high molar mass macromolecules,with Mn up to 105.Following these studies phosphorylation of polymers with side groups containing -OH groups were studied and a series of diblock copolymers with ionic and nonionic blocks were prepared.