Reversal of experimental hemorrhagic shock by dimethylphenylpiperazinium (DMPP). |
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Authors: | S Guarini C Bazzani S Tagliavini A Bertolini W Ferrari |
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Affiliation: | Institute of Pharmacology, University of Modena, Italy. |
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Abstract: | In a rat model of hemorrhagic shock which caused the death of all control rats within 30 min, i.v. injection of the ganglion-stimulating drug dimethylphenylpiperazinium (DMPP) caused a dose-dependent reversal of the shock condition--without the need for reinfusion of the shed blood--starting from the dose of 4 ng/kg i.v. Shock reversal was associated with the mobilization of residual blood and improvement in blood flow, particularly at the carotid level. These results could influence our thinking on pathophysiology and first-aid management of shock. |
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