| 硝基芳烃类化合物诱发体外人外周血淋巴细胞微核的研究 |
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| 引用本文： | 臧宇,王永兴,夏洁,钟远,孔志明,章敏. 硝基芳烃类化合物诱发体外人外周血淋巴细胞微核的研究[J]. 南京大学学报(自然科学版), 1997, 0(2) |
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| 作者姓名： | 臧宇 王永兴 夏洁 钟远 孔志明 章敏 |
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| 作者单位： | 污染控制与资源化研究国家重点实验室南京大学环境科学与工程系 |
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| 摘 要： | 应用人外周血淋巴细胞微核试验研究４种硝基芳烃类化合物的致突变性，结果表明邻二硝基苯，间二硝基苯，２，４－二硝基甲苯，２，６－二硝基甲苯均能诱发人外周血淋巴细胞的微核率增加，并且具有明显的剂量－效应关系。引进标准剂量（ｄｅｆｉｎｉｎｇｄｏｓｅ）概念比较４种硝基芳烃类的致突变性，结果表明４种硝基芳烃类的致突变性强弱为２，４－二硝基甲苯＞间二硝基苯＞２，６－二硝基甲苯＞邻二硝基苯。
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| 关 键 词： | 微核，人外周血淋巴细胞，硝基芳烃类化合物 |
STUDY ON MICRONUCLEUS INDUCED BY NITRO-AROMATIC COMPOUNDS IN HUMAN PERIPHERAL BLOOD LYMPHOCYTE IN VITRO |
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| Zang Yu Wang Yongxing Xia Jie Zhong Yuan Kong Zhiming Zhang Min. STUDY ON MICRONUCLEUS INDUCED BY NITRO-AROMATIC COMPOUNDS IN HUMAN PERIPHERAL BLOOD LYMPHOCYTE IN VITRO[J]. Journal of Nanjing University: Nat Sci Ed, 1997, 0(2) |
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| Authors: | Zang Yu Wang Yongxing Xia Jie Zhong Yuan Kong Zhiming Zhang Min |
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| Abstract: | The mutagenicity of M-dinitrobenzene,2,4 dinitrotoluene,2,6 dinitrotoluene,0 dinitrobenzene was analysed through a milronucieus test in human peripheral blood lymphocyte.The results show that all four nitro aromatic compounds induce micronucleus formation with significant dose effect relationships compared with defining dose, the mutagenicity of nitro aromatic compounds decreases as 2,4 dinitrotoluene,M dinitrobenzene,2,6 dinitrotoluene, O dinitrobenzene. |
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| Keywords: | Micronucleus Human peripheral blood lymphocyte Nitro-aromatic compounds |
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