| 1,4—二取代氨基脲的合成及抗菌活性 |
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| 引用本文： | 李建平 李永芳. 1,4—二取代氨基脲的合成及抗菌活性[J]. 河南师范大学学报(自然科学版), 1997, 25(2): 47-50 |
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| 作者姓名： | 李建平 李永芳 |
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| 作者单位： | 河南师范大学化学系 |
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| 摘 要： | 通过芳基脲与苯肼、苯甲酰肼的亲核取代反应和芳肼与尿素的亲核取代反应，合成了１５种新的１，４—二取代氨基脲化合物，其结构已经元素分析、ＩＲ、ＨＮＭＲ、ＭＳ等确证．初步生物活性试验表明对短小杆菌、沙门氏杆菌、绿脓杆菌、变形杆菌、金黄色葡萄球菌及根霉有不同程度的抗菌作用
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| 关 键 词： | 二取代氨基脲；合成；抗菌活性 |
Synthesis and Antibacterial Activity of 1,4-Disubstituted Semicarbazides |
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| Li Jianping Wang Yulu Wang Hong Zhao Shuhua Wang Xiaoyang Ma Donglan. Synthesis and Antibacterial Activity of 1,4-Disubstituted Semicarbazides[J]. Journal of Henan Normal University(Natural Science), 1997, 25(2): 47-50 |
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| Authors: | Li Jianping Wang Yulu Wang Hong Zhao Shuhua Wang Xiaoyang Ma Donglan |
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| Abstract: | In this paper, fifteen new 1,4-disubstituted semicarbazides were syntheszed. Their structure was identified by Elemental analysis, IR, HNMR and MS spectra. The preliminary biological altivity studies indicate that the compounds possess strong boetericidal action and bacteriostasis against Parrobacteria, Salmanella, Pselldomona aeruginosa, Proteus, Staphylococcus aureus and Rhizopus nigricions. |
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| Keywords: | disubstituted semicarbazide synthesis antibacterial activity |
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