| 可降解瓜尔胶载药微胶囊的聚乙二醇修饰 |
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| 引用本文： | 张黎明,欧富初,陈汝福.可降解瓜尔胶载药微胶囊的聚乙二醇修饰[J].中山大学学报(自然科学版),2005,44(1):45-48. |
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| 作者姓名： | 张黎明 欧富初 陈汝福 |
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| 作者单位： | 1. 中山大学化学与化学工程学院,广东,广州,510275
2. 中山大学附属第二医院,广东,广州,510120 |
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| 基金项目： | 国家自然科学基金，国家高技术研究发展计划(863计划)，广东省自然科学基金，广东省科技厅科技计划 |
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| 摘 要： | 通过将三聚磷酸纳溶液滴加到阳离子瓜尔胶和聚乙二醇(PEG)混合水溶液中,利用多糖聚电解质的离子凝胶化反应首次制得经PEG修饰的可降解瓜尔胶微胶囊,并用扫描电镜对其表面形态和粒径大小进行了考察;通过对不同浓度牛血清白蛋白和阿司匹林二种模型药物的负载实验,发现修饰后的微胶囊比未经修饰的微胶囊有增大的负载百分率和载药量.
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| 关 键 词： | 微胶囊 药物载体 瓜尔胶 聚乙二醇 牛血清白蛋白 阿司匹林 |
| 文章编号： | 0529-6579(2005)01-0045-04 |
| 修稿时间： | 2004年6月22日 |
Modification of Biodegradable Drug-loaded Guar Gum Microcapsules by Poly (ethylene glycol) |
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| ZHANG Li_ming,OU Fu_chu,CHEN Ru_fu.Modification of Biodegradable Drug-loaded Guar Gum Microcapsules by Poly (ethylene glycol)[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2005,44(1):45-48. |
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| Authors: | ZHANG Li_ming OU Fu_chu CHEN Ru_fu |
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| Institution: | ZHANG Li_ming~1,OU Fu_chu~1,CHEN Ru_fu~2 |
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| Abstract: | By adding tripolyphosphate solution dropwise into the mixed solutions of a cationic guar gum and poly(ethylene glycol) (PEG), the PEG_modified guar gum microcapsules with good biodegradability were prepared, resulting from the ionotropic gelation of the polyelectrolytes. The morphology and particle size of the resulting guar gum microcapsules were investigated by electron transmission microphotography. By investigating the encapsulation and loading percentages of the unmodified and PEG_modified guar gum microcapsules for two model drugs with various concentrations, bovine serum albumin and aspirin, an enhanced encapsulation and loading capacity was found for the PEG_modified guar gum microcapsules in comparison with the unmodified guar gum microcapsule. |
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| Keywords: | microcapsule drug carrier guar gum poly(ethylene glycol) bovine serum albumin aspirin |
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