In vitro bioactivity and cytocompatibility of porous scaffolds of bioactive borosilicate glasses |
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Authors: | Xin Zhang HaiLuo Fu Xin Liu AiHua Yao DePing Wang WenHai Huang Ying Zhao XinQuan Jiang |
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Institution: | 1 Institute of Bio-Engineering &|IT Materials, Center for Advanced Materials and Nano-Biomedicine, Tongji University, Shanghai 200092, China;
2 Department of Materials Science and Engineering, Missouri University of Science and Technology, Rolla MO 65409, USA;
3 Key Laboratory of the Advanced Civil Engineering Materials, Ministry of Education, Tongji University, Shanghai 200092, China;
4 Shanghai Ninth People’s Hospital, Shanghai 200011, China |
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Abstract: | The bioactive borosilicate scaffolds (R2O-RO-B2O3-SiO2-P2O5) with four different contents of borate were fabricated by replication technique. The bioactivity, degradability and the
cytotoxicity of the scaffolds were studied in this paper. The porosity of the scaffolds was found to be 73%–80%, and the pore
size was in the range of 200–300 μm. The porous scaffolds immersed in 0.02 mol·L−1 K2HPO4 solution were transformed into hydroxyapatite. And it is notable that the D-Alk-2B, D-Alk-3B-scaffolds were covered by hydroxyapatite
layers after 7 h-immersion, which proved their high bioactivity. In the cell adhesion test, cells could be seen growing well
on the scaffolds, showing stretched morphology and obvious pseudopodia, and only the high cumulative concentration of B ions
released from the D-Alk-3B-scaffold samples had an inhibition effect on cell proliferation. But the inhibition effect could
be alleviated by diluting the extract solution to a certain concentration (dilution ratio: 1:8). Therefore, after suitable
pretreatment, the porous borosilicate bioactive glass scaffold can be a desirable candidate for bone tissue engineering. |
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Keywords: | bioactivity borate glass controllable degradability MTT test cell adhesion test cytotoxicity |
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