Multiple daily amphetamine administration decreases both [3H]agoinst and [3]antagonist dopamine receptor binding |
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| Authors: | D R Sibley S Weinberger D S Segal I Creese |
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| Institution: | (1) Department of Neurosciences and Department of Psychiatry, University of California, San Diego, 92093 La Jolla, California, USA |
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| Abstract: | Summary Multiple daily amphetamine injections in rats decreased both 3H]agonist as well as 3H]antagonist striatal dopamine receptor binding. Concurrently, these animals exhibited a decrease in striatal dopamine concentration and, paradoxically, an enhancement of behavioral responsivity.This study was supported by PHS grant MH32990 to I.C. and DA0156805 to D.S.I. Creese and D. Segal are the recipients of the RSDA grants MH00316-01 and RSDA MH70183-08, respectively. |
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