Transformation of progesterone byCaldariella acidophila,an extreme thermophilic bacterium |
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| Authors: | M De Rosa A Gambacorta G Sodano A Trabucco |
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| Institution: | (1) Istituto per la Chimica di Molecole di Interesse Biologico del C.N.R., Via Toiano 2, Arco Felice, Naples, (Italy) |
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| Abstract: | Summary
Caldariella Acidophila, a thermophilic bacterium, converts porgesterone (1) to pregn-4-en-3,6,20-trione (2), 5a-pregnan-3, 6, 20-trione (3), pregn-4-en-20a-ol-3-one (4), pregn-4-6 -ol-3, 20-dione (5) and pregn-4-en-6a-ol-3, 20-dione (6). Different patterns of these metabolites were obtained by modifying the incubation conditions and using differently treated biocatalysis. |
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