Protection by chlorpromazine against lethality and renal toxicity of cisplatin in mice. |
| |
| Authors: | M Ishikawa M Ozaki Y Takayanagi K Sasaki |
| |
| Institution: | Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan. |
| |
| Abstract: | The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine given (i.p.) 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin. Chlorpromazine did not reduce the antitumor activity of cisplatin against Sarcoma 180 in ddY mice or EL-4 Leukemia in C57BL/6J mice. |
| |
| Keywords: | |
|
