| 2-（1-氢-四唑）-4′-甲基联苯的合成 |
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| 引用本文： | 常瑜,相会明,宋广慧. 2-（1-氢-四唑）-4′-甲基联苯的合成[J]. 太原理工大学学报, 2008, 39(2): 189-191 |
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| 作者姓名： | 常瑜 相会明 宋广慧 |
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| 作者单位： | 太原理工大学,化学化工学院,山西,太原,030024 |
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| 基金项目： | 山西省教委资助项目(960257) |
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| 摘 要： | 以三氟甲磺酸锌为催化剂,合成了沙坦类药物关键中间体2-(1-氢-四唑)-4′-甲基联苯。考察了原料配比、催化剂用量、溶剂用量和反应时间等因素对反应收率的影响,通过均匀设计方法优化了合成,使收率提高到91.8%。
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| 关 键 词： | 2-(1-氢-四唑)-4′-甲基联苯 四氮唑 均匀设计 合成 |
| 文章编号： | 1007-9432（2008）02-0189-03 |
| 收稿时间： | 2007-05-12 |
| 修稿时间： | 2007-05-01 |
Synthesis of 2-[-(trimethyl) tetrazole]-4'-methylbiphenyl |
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| CHANG Yu,XIANG Hui-ming,SONG Guang-hui. Synthesis of 2-[-(trimethyl) tetrazole]-4'-methylbiphenyl[J]. Journal of Taiyuan University of Technology, 2008, 39(2): 189-191 |
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| Authors: | CHANG Yu XIANG Hui-ming SONG Guang-hui |
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| Abstract: | 2-[(trimethyl)tetrazole]-4'-methylbiphenyl was synthesized by sodium azide and 2-cyano-4'-methylbiphenyl,using triflumethanesulfonic acid zinc as catalyst,the factors of materials ratio,reaction time,the amount of catalyst and solvent on the synthesis were studied by uniform experiment. The yield of 2-[(trimethyl)tetrazole]-4'-methylbiphenyl can reach 91.8%. |
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| Keywords: | 2-[(trimethyl)tetrazole]-4'-methylbiphenyl tetrazole uniform experiment design synthesis |
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