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Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter |
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| Authors: | Y Noma P Sideras T Naito S Bergstedt-Lindquist C Azuma E Severinson T Tanabe T Kinashi F Matsuda Y Yaoita |
| Abstract: | Complementary DNA encoding the IgG1 induction factor, the first lymphokine directed to B lymphocytes, from a murine T-cell line has been cloned using a new strategy. The putative primary amino-acid sequence was deduced from the nucleotide sequence determined. The lymphokine synthesized by the direction of this cloned cDNA has many other functions, such as production of B-cell growth factor-1 and induction of Ia on B cells. |
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