|
|||||
|
|
| 高效液相色谱法测定盐酸羟考酮罗痛定复方缓释片的含量 | |
| 引用本文： | 阴元魁 高永良 李明亚. 高效液相色谱法测定盐酸羟考酮罗痛定复方缓释片的含量[J]. 科学技术与工程, 2007, 7(19): 5046-5048 |
| 作者姓名： | 阴元魁 高永良 李明亚 |
| 作者单位： | 1. 广东药学院,广州,510006;军事医学科学院毒物药物研究所,北京,100850 2. 军事医学科学院毒物药物研究所,北京,100850 3. 广东药学院,广州,510006 |
| 摘 要： | 建立了测定复方羟考酮罗痛定缓释片中有效成分含量的方法。采用高效液相色谱法,检测波长225nm。在所测浓度范围内,峰面积与被测物浓度的线性关系,盐酸羟考酮和罗痛定的回收率分别是98.1%~100.3%和98.5%~99.0%,RSD值分别为1.11%~1.46%和0.19%~0.50%。测定方法简便、准确,灵敏度高,方法可靠,可作为该制剂的质量控制方法。 |
| 关 键 词： | 盐酸羟考酮 罗痛定 高效液相色谱法 测定 |
| 文章编号： | 1671-1819(2007)19-5046-03 |
| 修稿时间： | 2007-05-18 |
Determination of Oxycodone Hydrochloride and Rotundine in Compound Sustained-release Tables by HPLC |
|
| YIN Yuan-kui,GAO Yong-liang,LI Ming-ya. Determination of Oxycodone Hydrochloride and Rotundine in Compound Sustained-release Tables by HPLC[J]. Science Technology and Engineering, 2007, 7(19): 5046-5048 | |
| Authors: | YIN Yuan-kui GAO Yong-liang LI Ming-ya |
| Affiliation: | Guangdong Pharmacy College , Guangzhou 510006, P. R. China;Institute of Pharmacology and Toxicology the Academy of Military Medical Sciences, Beijing 100850, P. R. China |
| Abstract: | To establish a HPLC method for the determination of oxycodone hydrochloride and rotundine in com- pound sustained-release tables, detective wavelength was 280 nm. The results show that the standard curve is linear in the detection range. The average recovery rate is 98. 1% - 100.3% for oxycodone hydrochloride with RSD of 1.11% - 1.46% and 98.5% - 99.0% for rotundine with RSD of 0. 19% - 0.50%. This sensitive and reliable HPLC method is used to the quality control of compound sustained-release tables. |
| Keywords: | oxycodone hydrochloride rotundine high performance liquid chromatography determin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《科学技术与工程》浏览原始摘要信息 | |
| 点击此处可从《科学技术与工程》下载全文 | |