Änderung der Wachstumskinetik von Ehrlich-Aszitestumoren verschiedener Ploidie nach Röntgen-Bestrahlung

Summary The effect of irradiation (500 R) on the cell cycle of the diploid (EAT_dipl.) and the hypertetraploid (ELT) Ehrlich ascites tumor growing in the peritoneal cavity of male NMRI mice has been studied autoradio-graphically by the double labelling technique (H³- and C¹⁴-thymidine) and the method of labelled mitoses. The results suggest that the proliferation kinetics of tumor cells after irradiation depends on the type of tumor cell strain tested. Identical results were obtained after application of the alkylating agent cyclophosphamide (100 mg/kg).