Influence of sodium balance on atrial natriuretic factor in rats with one-kidney, one-clip renal hypertension |
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| Authors: | A L Lattion J P Flückiger B Waeber J Nussberger J F Aubert H R Brunner |
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| Institution: | Division of Hypertension, University Hospital, Lausanne, Switzerland. |
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| Abstract: | The influence of sodium intake on the gene expression and circulating levels of atrial natriuretic factor (ANF) was investigated in unanesthetized rats with one-kidney, one-clip renal hypertension. After clipping, the rats were maintained for 3 weeks either on a salt-deficient (n = 11) or a regular-sodium diet (n = 10). Animals which had received the regular-sodium diet exhibited significantly higher ANF mRNA levels in their right and left atria than salt-restricted animals, whereas there was no significant difference in plasma ANF levels. |
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