Colcemid effects on homologue pairing and crossing over during fetal mouse oogenesis |
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| Authors: | G Jagiello W K Sung J S Fang M B Ducayen |
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| Affiliation: | Department of Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University, New York 10032. |
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| Abstract: | Colcemid was administered to gestational day 13 female mice to test effects on homologue pairing, synapsis and recombination of fetal oogenesis. Pairing abnormalities were detected in pachytene oocytes by light and electron microscopy examination of bivalents and synaptonemal complexes. Reduction of total chiasmata per treated diplotene oocyte (22.74) compared to controls (31.07) was found. |
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