Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain |
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Authors: | B Binétruy T Smeal M Karin |
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Institution: | Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla 92093. |
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Abstract: | Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts. |
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