Intra-vascular glucocorticoid metabolism as a modulator of vascular structure and function |
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Authors: | P W F Hadoke L Macdonald J J Logie G R Small A R Dover B R Walker |
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Institution: | (1) Endocrinology Unit, Centre for Cardiovascular Science, Edinburgh University, The Queen’s Medical Research Institute, 47, Little France Crescent, Edinburgh, EH16 4TJ, Scotland (United Kingdom) |
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Abstract: | The ability of glucocorticoids to directly alter arterial function, structure and the inflammatory response to vascular injury
may contribute to their well-established link with the development of cardiovascular disease. Recent studies have emphasised
the importance of tissue-specific regulation of glucocorticoid availability by the 11 β-hydroxysteroid dehydrogenase (11HSD)
isozymes, which inter-convert active glucocorticoids and their inactive metabolites. The expression of both type 1 and type
2 11HSDs in the arterial wall suggests that prereceptor metabolism of glucocorticoids may have a direct impact on vascular
physiology. Indeed there is evidence that 11HSDs influence glucocorticoid-mediated changes in vascular contractility, vascular
structure, the inflammatory response to injury and the growth of new blood vessels. Hence, inhibition of 11HSD isozymes may
provide a novel therapeutic target in vascular disease.
Received 19 September 2005; received after revision 1 November 2005; accepted 25 November 2005 |
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Keywords: | 11β -Hydroxysteroid dehydrogenase inflammation vascular contractility angiogenesis cardiovascular disease |
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