| 黑尾胡蜂毒液抗菌肽的分离纯化及功能研究 |
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| 引用本文： | 王滢,张广求,屈睿,潘世甜,李素娟.黑尾胡蜂毒液抗菌肽的分离纯化及功能研究[J].云南民族大学学报(自然科学版),2015(2):119-122. |
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| 作者姓名： | 王滢 张广求 屈睿 潘世甜 李素娟 |
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| 作者单位： | 云南民族大学民族药资源化学国家民委-教育部重点实验室 |
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| 基金项目： | 国家自然科学基金(31460571);民族药资源化学国家民委-教育部重点实验室开放基金(MZY1403);云南民族大学青年基金科研项目(2013QN24);云南民族大学引进人才科研项目(2014RC005) |
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| 摘 要： | 由于病原微生物对众多传统抗生素药物的耐药性问题日益突显,因此寻找新型的抗菌药物显得尤为紧迫,多肽类制剂因其具有广谱的抗菌活性,已成为克服病原微生物耐药性的潜在候选药物.从黑尾胡蜂毒液中分离并鉴定了一种具有抗菌活性的多肽,命名为VT-1.VT-1对临床致病菌均表现出广谱的抗菌活性.此外,VT-1对人红细胞显示出微弱的溶血活性.
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| 关 键 词： | 黑尾胡蜂 毒腺 抗菌肽 |
Purification and functions of the antimicrobial peptide from the venom gland of the social wasp Vespa tropica |
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| WANG Ying;ZHANG Guang-qiu;QU Rui;PAN Shi-tian;LI Su-juan.Purification and functions of the antimicrobial peptide from the venom gland of the social wasp Vespa tropica[J].Journal of Yunnan Nationalities University:Natural Sciences Edition,2015(2):119-122. |
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| Authors: | WANG Ying;ZHANG Guang-qiu;QU Rui;PAN Shi-tian;LI Su-juan |
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| Institution: | WANG Ying;ZHANG Guang-qiu;QU Rui;PAN Shi-tian;LI Su-juan;Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission and Ministry of Education of China,Yunnan Minzu University; |
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| Abstract: | Peptide agents are regarded as potential candidates for overcoming the life-threatening resistance of pathogenic microorganisms to classic antibiotics. This research has identified an antimicrobial peptide,namely VT-1 from the venom gland of the wasp Vespa tropica,by using the combined methods of peptidomics and genomics.VT-1 has exerted a broad-spectrum antimicrobial activity against standard and clinically isolated strains of bacteria. In addition,VT-1 shows a weak hemolytic activity toward human erythrocytes. |
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| Keywords: | Vespa tropica venom gland antimicrobial peptide |
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