Sr2+ can become incorporated into an agonist-sensitive,cytoplasmic Ca2+ store in a cell line derived from the equine sweat gland epithelium期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Sr2+ can become incorporated into an agonist-sensitive,cytoplasmic Ca2+ store in a cell line derived from the equine sweat gland epithelium

Authors:	W H Ko J D Pediani D L Bovell S M Wilson

Institution:	(1) Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, West Medical Building, G12 8QQ Glasgow, (Scotland, UK);(2) Department of Biological Sciences, Glasgow Caledonian University, G13 1PP Glasgow, (Scotland, UK);(3) Department of Physiology, The Chinese University of Hong Kong, (Hong Kong)

Abstract:	We have explored the properties of a Ca²⁺-dependent cell-signalling pathway that becomes active when cultured equine sweat gland cells are stimulated with ATP. The ATP-regulated, Ca²⁺-influx pathway allowed Sr²⁺ to enter the cytoplasm but permitted only a minimal influx of Ba²⁺. Experiments in which cells were repeatedly stimulated with ATP suggested that Sr²⁺, but not Ba²⁺, could become incorporated into the agonist-sensitive, cytoplasmic Ca²⁺ store. Further evidence for this was provided by experiments using ionomycin, a Ca²⁺ ionophore which has no affinity for Sr²⁺.

Keywords:	Ca²⁺ mobilisation purinergic receptors nucleotide receptors sweat gland epithelial cells ionomycin Fura-2 horse
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