| 微波辐射合成阿司匹林的研究 |
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| 引用本文： | 王彩霞,徐翠莲,樊素芳,杨国玉. 微波辐射合成阿司匹林的研究[J]. 河南科学, 2010, 28(11): 1396-1397 |
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| 作者姓名： | 王彩霞 徐翠莲 樊素芳 杨国玉 |
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| 作者单位： | 河南农业大学,理学院,化学系,郑州,450002;河南农业大学,理学院,化学系,郑州,450002;河南农业大学,理学院,化学系,郑州,450002;河南农业大学,理学院,化学系,郑州,450002 |
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| 摘 要： | 以水杨酸和乙酸酐为原料,选用不同催化剂,用微波法快速合成阿司匹林.通过实验考察了原料用量比、不同催化剂、微波辐射功率、辐射时间等因素对产率的影响,得到了最佳合成工艺条件:水杨酸和乙酸酐量的比为1∶1.5,微波功率为550 W,用乙酸钾作催化剂,辐射时间5 min时,纯化后产物产率高达81.46%.
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| 关 键 词： | 阿司匹林 催化合成 微波辐射 |
Microwave-Induced Synthesis of Aspirin on Different Catalysts |
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| Wang Caixia,Xu Cuilian,Fan Sufang,Yang Guoyu. Microwave-Induced Synthesis of Aspirin on Different Catalysts[J]. Henan Science, 2010, 28(11): 1396-1397 |
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| Authors: | Wang Caixia Xu Cuilian Fan Sufang Yang Guoyu |
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| Affiliation: | (College of Science, Henan Agricultural University, Zhengzhou 450002, China) |
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| Abstract: | Aspirin was synthesized through O-acylating reaction from salicylic acid and acetic anhydride by microwave radiation with sodium acetate as catalyst. Several factors influencing on the reaction yield such as the kind of catalysts,the ratio of salicylic acid to acetic anhydride,the power of microwave radiation, the time of microwave radiation and thc optimum method was gained. The result indicates that microwave synthesis has many advantages including simplification in method, time saving, no pollution and good quality for the sample. The method is suitable for green chemical synthesis in industrial producing. |
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| Keywords: | Aspirin catalyze synthesis microwave（radiation） |
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