| 金针菇多糖对衰老小鼠脾脏抗氧化能力的影响 |
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| 引用本文： | 姜秀梅,徐小磊,殷一民,张梦洁,孙彤,张文静,徐文帅. 金针菇多糖对衰老小鼠脾脏抗氧化能力的影响[J]. 北华大学学报(自然科学版), 2016, 17(4): 488-491. DOI: 10.11713/j.issn.1009-4822.2016.04.013 |
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| 作者姓名： | 姜秀梅 徐小磊 殷一民 张梦洁 孙彤 张文静 徐文帅 |
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| 作者单位： | 北华大学公共卫生学院,吉林 吉林,132013;北华大学公共卫生学院,吉林 吉林,132013;北华大学公共卫生学院,吉林 吉林,132013;北华大学公共卫生学院,吉林 吉林,132013;北华大学公共卫生学院,吉林 吉林,132013;北华大学公共卫生学院,吉林 吉林,132013;北华大学公共卫生学院,吉林 吉林,132013 |
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| 基金项目： | 吉林市科技发展计划项目(201536061)，大学生国家级创新项目(201410201058)，北华大学大学生校级创新项目(201300181) |
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| 摘 要： | 目的探讨金针菇多糖对衰老小鼠脾脏抗氧化能力的影响及金针菇多糖的抗衰老机制.方法 ICR小鼠60只,雌雄各半,按体质量随机分为6组:空白对照组,模型组,脑复康组,金针菇多糖(FVP)低、中、高剂量组.实验动物喂饲6周,处死小鼠,取脾组织,计算小鼠脾脏指数;测量脾脏抗氧化指标MDA,SOD,GSH-Px.结果与模型组比较,金针菇多糖组脾脏指数显著下降(P0.05),MDA含量显著下降(P0.05),GSH-Px和SOD活性显著上升(P0.05).结论金针菇多糖可使衰老小鼠脾脏产生抗氧化作用,可能是金针菇多糖抗衰老的作用机制之一.
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| 关 键 词： | 金针菇多糖 小鼠 脾脏 抗氧化 |
Effect of Polysaccharides from Flammulina velutipes on the Antioxidant Capacity of Spleen in Aging Mice |
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| Jiang Xiumei,Xu Xiaolei,Yin Yimin,Zhang Mengjie,Sun Tong,Zhang Wenjing,Xu Wenshuai. Effect of Polysaccharides from Flammulina velutipes on the Antioxidant Capacity of Spleen in Aging Mice[J]. Journal of Beihua University(Natural Science), 2016, 17(4): 488-491. DOI: 10.11713/j.issn.1009-4822.2016.04.013 |
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| Authors: | Jiang Xiumei Xu Xiaolei Yin Yimin Zhang Mengjie Sun Tong Zhang Wenjing Xu Wenshuai |
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| Abstract: | Objective To study the effect of polysaccharides from Flammulina velutipes ( FVP ) on the antioxidant capacity of spleen in aging mice, and to investigate its anti-aging mechanism. Method Sixty ICR mice with half males and half females were randomly divided into six groups according to their body weights, including blank control group,model group,piracetam group,FVP low,medium and high dose group. The mice were raised for six weeks,and were sacrificed at the end of the experiment. The spleens were obtained and the spleen indexes were calculated. The antioxidant indexes including MDA, SOD and GSH-Px in spleen were determined. Results Compared to the model group, spleen indexes and MDA contents in FVP groups significantly decreased (P<0. 05),and the activities of GSH-Px and SOD significantly increased (P<0. 05). Conclusion FVP can induce the antioxidant effect of spleen in aging mice,which may be one of the anti-aging mechanism of FVP . |
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| Keywords: | FVP mice spleen antioxidant |
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