双氯芬酸钾乳胶剂的抗炎镇痛作用研究

目的考查自制的双氯芬酸钾乳胶剂的抗炎镇痛作用及有效性.方法采用小鼠二甲苯致耳肿胀实验、皮肤毛细血管通透性实验及小鼠扭体反应实验3种模型比较自制的双氯芬酸钾乳胶剂和市售扶他林乳胶的抗炎作用和镇痛作用的区别.结果与空白组比较,双氯芬酸钾乳胶剂与扶他林均具有显著的抗炎镇痛作用.自制的双氯芬酸钾乳胶剂的耳肿胀抑制率和疼痛抑制率高于阳性药扶他林,但双氯芬酸钾乳胶剂的小鼠腹部皮肤毛细血管通透性抑制率低于阳性药扶他林.结论自制双氯芬酸钾乳胶剂与扶他林比较具有较强的全身抗炎镇痛作用.

On the Anti-inflammatory and Analgesic Effects of Diclofenac Potassium Emulgel

Objective To study the anti-inflammatory and analgesic effects of self-made diclofenac potassium emulgel,and to evaluate the efficiency of the emulgel. Method The anti-inflammatory and analgesic effects were compared between the self-made diclofenac potassium emulgel and purchased Votalin emulgel based on three animal models,including ear swelling and capillary permeability of abdominal skin induced by xylene in mice, and writhing response induced by acetic acid in mice. Results Compared with the control group,both the self-made emulgel and purchased emulgel exhibited obvious anti-inflammatory and analgesic effects. The ear swelling inhibition ratio and pain inhibition ratio of the self-made emulgel were both higher than those of vltaren emulgel. While,the capillary permeability inhibition ratio of the self-made was lower than that of the positive control. Conclusion Compared with Votalin, the self-made diclofenac potassium emulgel has better anti-inflammatory and analgesic effects in the whole body.