| 真核翻译延伸因子eEF1A功能研究进展 |
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| 引用本文： | 高爽,查笑君,潘建伟.真核翻译延伸因子eEF1A功能研究进展[J].浙江师范大学学报(自然科学版),2013(4):444-449. |
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| 作者姓名： | 高爽 查笑君 潘建伟 |
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| 作者单位： | 浙江师范大学化学与生命科学学院,浙江金华321004 |
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| 基金项目： | 国家自然科学基金资助项目（31000741;31171520） |
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| 摘 要： | 总结了近年来对于真核翻译延伸因子eEF1A生物学功能和作用机制研究的一些新进展，具体包括：eEF1A参与介导受损或错误折叠的蛋白质的降解；对微丝、微管骨架系统的组织与调控；参与调控细胞凋亡；参与细胞核输出氨酰一tRNA；与病毒基因组和RNA依赖性RNA聚合酶类（RNA-dependent RNA polymerase，RdRP）互作，参与病毒繁殖．阐述了对eEF1A进行研究的意义和价值，并提供了新的见解和展望．
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| 关 键 词： | 真核生物 翻译延伸因子1A（eEF1A） 功能 作用机制 |
Research advances on the biological functions of eukaryotic translation elongation factor |
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| GAO Shuang,ZHA Xiaojun,PAN Jianwei.Research advances on the biological functions of eukaryotic translation elongation factor[J].Journal of Zhejiang Normal University Natural Sciences,2013(4):444-449. |
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| Authors: | GAO Shuang ZHA Xiaojun PAN Jianwei |
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| Institution: | (College of Chemistry and Life Science, Zhejiang Normal University, Jinhua Zhejiang 321004, China) |
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| Abstract: | It was summarized recent advances in the biological functions and action mechanisms of eukaryotic translation elongation factor （ eEF1 A ） including mediating the proteolysis of damaged or misfolded proteins, regulating the organization of actin and microtubule cytoskeleton, regulating of apoptosis, mediating the nucle-ar export of aa-tRNAs, and interacting with the viral genome and RdRPs during viral propagation. The signifi-cance and value of the study of eEF1 A were pointed out and new insights and perspectives were predicted. |
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| Keywords: | eucaryote translation elongation factor 1 A （ eEF1 A ） function mechanism |
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