| 可跨膜SOD对肝癌及正常肝细胞增殖的作用 |
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| 引用本文： | 刘树滔,陆重益,赵花琴,张晨,饶平凡. 可跨膜SOD对肝癌及正常肝细胞增殖的作用[J]. 福州大学学报(自然科学版), 2011, 39(3): 460-463 |
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| 作者姓名： | 刘树滔 陆重益 赵花琴 张晨 饶平凡 |
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| 作者单位： | 福州大学生物工程研究所; |
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| 摘 要： | 可跨膜融合蛋白PTD-SOD与肝癌细胞和正常肝细胞共培养,使细胞内SOD活力分别增加了52%和23%,提高胞内总抗氧化能力(T-AOC)水平达100%,同时降低ROS水平.实验结果显示,肝癌细胞增殖受到显著抑制,最高抑制率达91.91%,对正常肝细胞抑制率较小,为45.50%.
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| 关 键 词： | PTD-SOD 肝癌 抗氧化 自由基 细胞 |
Effects of transductable SOD on the proliferation of hepatocarcinoma and normal hepatic cell lines |
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| LIU Shu-tao,LU Chong-yi,ZHAO Hua-qin,ZHANG Chen,RAO Ping-fan. Effects of transductable SOD on the proliferation of hepatocarcinoma and normal hepatic cell lines[J]. Journal of Fuzhou University(Natural Science Edition), 2011, 39(3): 460-463 |
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| Authors: | LIU Shu-tao LU Chong-yi ZHAO Hua-qin ZHANG Chen RAO Ping-fan |
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| Affiliation: | LIU Shu-tao,LU Chong-yi,ZHAO Hua-qin,ZHANG Chen,RAO Ping-fan(Institute of Biotechnology,Fuzhou University,Fuzhou,Fujian 350002,China) |
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| Abstract: | Incubated with PTD-SOD(PTD,protein transduction domain;SOD,superoxide dismutase) fused protein,the intracellular SOD activity of HepG2 and L-02 cell lines increased obviously,by 52% and 23% respectively.Intracellular total antioxidant capacity(T-AOC) was up to 100% and ROS level was decreased remarkably as well.Dates showed that the proliferation of HepG2 cell was significantly suppressed,up to 91.91%;while that of L-02 cell was only to 45.50%. |
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| Keywords: | PTD-SOD hepatoma antioxidant free radical cell |
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