菠萝蜜低聚肽对db/db糖尿病小鼠血糖的影响

 关于菠萝蜜的研究显示其具有一定的降血糖作用，但尚未有关于菠萝蜜低聚肽（Jack-fruit oligopeptides，JOPs）降血糖的研究。通过菠萝蜜低聚肽干预，研究其对db/db糖尿病模型小鼠血糖的影响作用。将db/db糖尿病小鼠模型，随机分为3个菠萝蜜低聚肽组（0.2 g/kg·bw、0.4 g/kg·bw、0.8 g/kg·bw）以及糖尿病模型对照组、二甲双胍对照组、乳清蛋白对照组；并选用db/m小鼠作为非糖尿病小鼠空白对照。经过为期6周的干预，检测小鼠空腹血糖、糖耐量实验血糖曲线下面积及组织中糖原含量。结果表明，菠萝蜜低聚肽可显著降低db/db糖尿病小鼠空腹血糖水平，显著降低糖耐量实验血糖曲线下面积（P<0.05），其效果以0.4 g/kg·bw剂量组最为显著。菠萝蜜低聚肽干预可有效降低糖尿病小鼠的血糖水平，改善糖耐量，具有辅助降血糖作用。

The hypoglycemic effects of jackfruit oligopeptides in db/db diabetic mice

To study the hypoglycemic effects of jackfruit oligopeptides in db/db diabetic mice, 48 db/db diabetic mice are randomly divided into six groups (with 8 mice in each group):three jackfruit oligopeptides groups (with 0.2 g/kg·bw, 0.4 g/kg·bw and 0.8 g/kg·bw JOPs, respectively, by intragastric administration), a diabetic model group, a metformin control group (with 0.2 g/kg·bw metformin hydrochloride enteric-coated tablets aqueous solution by intragastric administration) and a whey protein control group (with 0.4 g/kg·bw whey protein aqueous solution by intragastric administration), while 10 db/m mice are used as the blank control for non-diabetic mice. The fasting glucose, the OGTT-AUC, the liver glycogen and the muscle glycogen are measured during the intervention. It is shown that the JOPs could decrease the fasting blood glucose and the OGTT-AUC in the diabetic mice (P<0.05), especially in the 0.4g/kg·bw-dose group. The long-term jackfruit oligopeptides intervention can effectively reduce the blood glucose level and improve the glucose tolerance of diabetic mice.