Mechanisms of protein toxicity in neurodegenerative diseases |
| |
Authors: | Chang Geon Chung Hyosang Lee Sung Bae Lee |
| |
Institution: | 1.Department of Brain and Cognitive Sciences,DGIST,Daegu,Republic of Korea |
| |
Abstract: | Protein toxicity can be defined as all the pathological changes that ensue from accumulation, mis-localization, and/or multimerization of disease-specific proteins. Most neurodegenerative diseases manifest protein toxicity as one of their key pathogenic mechanisms, the details of which remain unclear. By systematically deconstructing the nature of toxic proteins, we aim to elucidate and illuminate some of the key mechanisms of protein toxicity from which therapeutic insights may be drawn. In this review, we focus specifically on protein toxicity from the point of view of various cellular compartments such as the nucleus and the mitochondria. We also discuss the cell-to-cell propagation of toxic disease proteins that complicates the mechanistic understanding of the disease progression as well as the spatiotemporal point at which to therapeutically intervene. Finally, we discuss selective neuronal vulnerability, which still remains largely enigmatic. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|