Critical effects of epigenetic regulation in pulmonary arterial hypertension |
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| Authors: | Dewei Chen Wenxiang Gao Shouxian Wang Bing Ni Yuqi Gao |
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| Affiliation: | 1.Department of Pathophysiology and High Altitude Pathology, College of High Altitude Military Medicine,Third Military Medical University,Chongqing,People’s Republic of China;2.Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine,Third Military Medical University,Chongqing,People’s Republic of China;3.Key Laboratory of High Altitude Medicine of PLA, College of High Altitude Military Medicine,Third Military Medical University,Chongqing,People’s Republic of China |
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| Abstract: | Pulmonary arterial hypertension (PAH) is characterized by persistent pulmonary vasoconstriction and pulmonary vascular remodeling. The pathogenic mechanisms of PAH remain to be fully clarified and measures of effective prevention are lacking. Recent studies; however, have indicated that epigenetic processes may exert pivotal influences on PAH pathogenesis. In this review, we summarize the latest research findings regarding epigenetic regulation in PAH, focusing on the roles of non-coding RNAs, histone modifications, ATP-dependent chromatin remodeling and DNA methylation, and discuss the potential of epigenetic-based therapies for PAH. |
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