Control of DNA integrity in skeletal muscle under physiological and pathological conditions |
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| Authors: | Yara Bou Saada Vlada Zakharova Boris Chernyak Carla Dib Gilles Carnac Svetlana Dokudovskaya Yegor S Vassetzky |
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| Institution: | 1.UMR 8126, CNRS, Univ. Paris-Sud,Université Paris Saclay, Institut de Cancérologie Gustave-Roussy,Villejuif,France;2.Belozersky Institute of Physico-Chemical Biology,Lomonosov Moscow State University,Moscow,Russia;3.PhyMedExp, INSERM U1046, CNRS UMR 9214,University of Montpellier,Montpellier Cedex 5,France;4.Koltzov Institute of Developmental Biology,Moscow,Russia |
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| Abstract: | Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health. |
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