MicroRNA regulation and analytical methods in cancer cell metabolism |
| |
| Authors: | Ling-Fei Zhang Shuai Jiang Mo-Fang Liu |
| |
| Institution: | 1.Center for RNA Research, State Key Laboratory of Molecular Biology,University of Chinese Academy of Sciences, CAS Center for Excellence in Molecular Cell Science,Shanghai,China;2.Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,China;3.Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences,Fudan University,Shanghai,China;4.Division of Biology and Biological Engineering,California Institute of Technology,Pasadena,USA;5.School of Life Science and Technology,Shanghai Tech University,Shanghai,China |
| |
| Abstract: | The reprogramming of glucose metabolism from oxidative to glycolytic metabolism, known as the Warburg effect, is an anomalous characteristic of cancer cell metabolism. Recent studies have revealed a subset of microRNAs (miRNAs) that play critical roles in regulating the reprogramming of glucose metabolism in cancer cells. These miRNAs regulate cellular glucose metabolism by directly targeting multiple metabolic genes, including those encoding key glycolytic enzymes. In the first part of this review, we summarized the recent knowledge of miRNA regulation in the reprogramming of glucose metabolism in cancer cells and discussed the potential utilization of the key miRNA regulators as metabolic targets for developing new antitumor agents. Then, we summarized recent advances in methods and techniques for studying miRNA regulation in cancer cell metabolism. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
