Emerging Role of MicroRNAs in mTOR Signaling |
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| Authors: | Yanjie Zhang Bo Huang Hui-Yun Wang Augustus Chang X. F. Steven Zheng |
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| Affiliation: | 1.Oncology Department, Shanghai Ninth People’s Hospital,Shanghai Jiaotong University School of Medicine,Shanghai,China;2.State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine,Sun Yat-Sen University Cancer Center,Guangzhou,China;3.Rutgers Robert Wood Johnson Medical School,Piscataway,USA;4.Rutgers Cancer Institute of New Jersey, Rutgers,The State University of New Jersey,New Brunswick,USA |
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| Abstract: | Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase that plays a critical role in the control of cellular growth and metabolism. Hyperactivation of mTOR pathway is common in human cancers, driving uncontrolled proliferation. MicroRNA (miRNA) is a class of short noncoding RNAs that regulate the expression of a wide variety of genes. Deregulation of miRNAs is a hallmark of cancer. Recent studies have revealed interplays between miRNAs and the mTOR pathway during cancer development. Such interactions appear to provide a fine-tuning of various cellular functions and contribute qualitatively to the behavior of cancer. Here we provide an overview of current knowledge regarding the reciprocal relationship between miRNAs and mTOR pathway: regulation of mTOR signaling by miRNAs and control of miRNA biogenesis by mTOR. Further research in this area may prove important for the diagnosis and therapy of human cancer. |
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