Impact of DNA repair and stability defects on cortical development |
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Authors: | Federico T Bianchi Gaia E Berto Ferdinando Di Cunto |
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Institution: | 1.Neuroscience Institute Cavalieri Ottolenghi,Turin,Italy;2.Department of Molecular Biotechnology and Health Sciences,University of Turin,Turin,Italy;3.Department of Neuroscience,University of Turin,Turin,Italy |
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Abstract: | Maintenance of genome stability is a crucial cellular function for normal mammalian development and physiology. However, despite the general relevance of this process, genome stability alteration due to genetic or non-genetic conditions has a particularly profound impact on the developing cerebral cortex. In this review, we will analyze the main pathways involved in maintenance of genome stability, the consequences of their alterations with regard to central nervous system development, as well as the possible molecular and cellular basis of this specificity. |
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