Anatomy of autophagy: from the beginning to the end |
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Authors: | Xiaoyong Zhi Wenzhi Feng Yueguang Rong Rong Liu |
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Institution: | 1.Department of Food Science, College of Food Science and Technology,Nanjing Agricultural University,Nanjing,China;2.Department of Ophthalmology,UT Southwestern Medical Center,Dallas,USA;3.Department of Pathogen Biology, School of Basic Medicine,Huazhong University of Science and Technology,Wuhan,China |
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Abstract: | Autophagy is a highly regulated process in eukaryotes to maintain homeostasis and manage stress responses. Understanding the regulatory mechanisms and key players involved in autophagy will provide critical insights into disease-related pathogenesis and potential clinical treatments. In this review, we describe the hallmark events involved in autophagy, from its initiation, to the final destruction of engulfed targets. Furthermore, based on structural and biochemical data, we evaluate the roles of key players in these processes and provide rationale as to how they control autophagic events in a highly ordered manner. |
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