Metabolic changes during B cell differentiation for the production of intestinal IgA antibody |
| |
| Authors: | " target="_blank">Jun Kunisawa |
| |
| Institution: | 1.Laboratory of Vaccine Materials,National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN),Ibaraki,Japan;2.Division of Mucosal Immunology, Department of Microbiology and Immunology and International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science,The University of Tokyo,Tokyo,Japan;3.Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, Graduate School of Dentistry,Osaka University,Osaka,Japan;4.Department of Microbiology and Infectious Diseases,Kobe University Graduate School of Medicine,Kobe,Japan |
| |
| Abstract: | To sustain the bio-energetic demands of growth, proliferation, and effector functions, the metabolism of immune cells changes dramatically in response to immunologic stimuli. In this review, I focus on B cell metabolism, especially regarding the production of intestinal IgA antibody. Accumulating evidence has implicated not only host-derived factors (e.g., cytokines) but also gut environmental factors, including the possible involvement of commensal bacteria and diet, in the control of B cell metabolism during intestinal IgA antibody production. These findings yield new insights into the regulation of immunosurveillance and homeostasis in the gut. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
