Post-translational regulation of the maternal-to-zygotic transition |
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| Authors: | Chao Liu Yanjie Ma Yongliang Shang Ran Huo Wei Li |
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| Institution: | 1.State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology,Chinese Academy of Sciences,Beijing,People’s Republic of China;2.State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology,Nanjing Medical University,Nanjing,People’s Republic of China;3.Department of Animal Science and Technology,Northeast Agricultural University,Haerbin,People’s Republic of China;4.College of Life Sciences,University of Chinese Academy of Sciences,Beijing,People’s Republic of China;5.State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology,Nanjing Medical University,Nanjing,People’s Republic of China |
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| Abstract: | The maternal-to-zygotic transition (MZT) is essential for the developmental control handed from maternal products to newly synthesized zygotic genome in the earliest stages of embryogenesis, including maternal component (mRNAs and proteins) degradation and zygotic genome activation (ZGA). Various protein post-translational modifications have been identified during the MZT, such as phosphorylation, methylation and ubiquitination. Precise post-translational regulation mechanisms are essential for the timely transition of early embryonic development. In this review, we summarize recent progress regarding the molecular mechanisms underlying post-translational regulation of maternal component degradation and ZGA during the MZT and discuss some important issues in the field. |
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