Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy |
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| Authors: | Jin Zhang Guan Wang Yuxin Zhou Yi Chen Liang Ouyang Bo Liu |
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| Institution: | 1.State Key Laboratory of Biotherapy and Cancer Center, West China Hospital,Sichuan University, and Collaborative Innovation Center of Biotherapy,Chengdu,China;2.College of Biological Sciences,China Agricultural University,Beijing,China;3.Department of Gastrointestinal Surgery, West China Hospital,Sichuan University,Chengdu,China |
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| Abstract: | Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process for the clearance of damaged or superfluous proteins and organelles. Accumulating studies have recently revealed that autophagy is closely related to a variety of types of cancer; however, elucidation of its Janus role of either tumor-suppressive or tumor-promoting still remains to be discovered. In this review, we focus on summarizing the context-dependent role of autophagy and its complicated molecular mechanisms in different types of cancer. Moreover, we discuss a series of small-molecule compounds targeting autophagy-related proteins or the autophagic process for potential cancer therapy. Taken together, these findings would shed new light on exploiting the intricate mechanisms of autophagy and relevant small-molecule compounds as potential anti-cancer drugs to improve targeted cancer therapy. |
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