Hh signaling in regeneration of the ischemic heart |
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| Authors: | Marina Dunaeva Johannes Waltenberger |
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| Affiliation: | 1.Department of Biomolecular Chemistry, Institute for Molecules and Materials and Radboud Institute for Molecular Life Sciences,Radboud University Nijmegen,Nijmegen,The Netherlands;2.Chair of Internal Medicine, Cardiology and Vascular Medicine, Division of Cardiology, Department of Cardiovascular Medicine,University Hospital Münster,Münster,Germany;3.Cells-in-Motion Cluster of Excellence (EXC 1003—CiM),University of Münster,Münster,Germany |
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| Abstract: | Myocardial infarction (MI) is caused by the occlusion of a coronary artery due to underlying atherosclerosis complicated by localized thrombosis. The blockage of blood flow leads to cardiomyocyte (CM) death in the infarcted area. Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury; however, some pathways active during embryogenesis and silent during adult life are recruited in response to tissue injury. One such example is hedgehog (Hh) signaling. Hh is involved in the embryonic development of the heart and coronary vascular system. Pathological conditions including ischemia activate Hh signaling in adult tissues. This review highlights the involvement of Hh signaling in ischemic tissue regeneration with a particular emphasis on heart regeneration and discusses its potential role as a therapeutic agent. |
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