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Unravelling the signal-transduction network in B lymphocytes
Authors:Sambrano Gilberto R  Chandy Grischa  Choi Sangdun  Decamp Dianne  Hsueh Robert  Lin Keng-Mean  Mock Dennis  O'Rourke Nancy  Roach Tamara  Shu Hongjun  Sinkovits Bob  Verghese Mary  Bourne Henry
Affiliation:Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA. sambrano@cmp.ucsf.edu
Abstract:The Alliance for Cellular Signaling has chosen the mouse B lymphocyte as a model system to understand basic principles that govern cellular signalling. Progress to that end has focused initially on establishing a reproducible experimental cell system and characterizing essential signalling responses. Although unravelling this complex network will take years, findings revealed in the interim will prove immensely useful to the scientific community at large.
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