Effect of propylene glycol and ethanol on3H-noradrenaline efflux from an isolated blood vessel

Summary Propylene glycol (14 mM), but not ethanol (17 mM), enhanced the late phase of passive³H-efflux from rabbit isolated aortic rings preloaded with³H-(–)-noradrenaline. We conclude that, with regard to³H-noradrenaline release studies, propylene glycol is unsuitable for aiding the dissolution of e.g. corticosterone in physiological salt solution, while ethanol can be used for this purpose.This study was supported by the Danish Medical Research Council. The authors gratefully acknowledge the technical assistance of Miss Mariann Wolmar.