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Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus |
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| Authors: | M D Waterfield G T Scrace N Whittle P Stroobant A Johnsson A Wasteson B Westermark C H Heldin J S Huang T F Deuel |
| Abstract: | A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A region of 104 contiguous amino acids shows virtual identity with the predicted sequence of p28sis, the putative transforming protein of simian sarcoma virus (SSV). This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors. |
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