| 4种11-脱氧甘草次酸3,30一双糖链皂苷的合成 |
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| 引用本文： | 王军,文伟河,胡小丽,朱玉亮. 4种11-脱氧甘草次酸3,30一双糖链皂苷的合成[J]. 南京工业大学学报(自然科学版), 2012, 34(1): 130-134 |
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| 作者姓名： | 王军 文伟河 胡小丽 朱玉亮 |
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| 作者单位： | 1. 江苏警官学院公安科技系,江苏南京210012;南京工业大学生物与制药工程学院,江苏南京210009
2. 南京工业大学生物与制药工程学院,江苏南京,210009 |
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| 摘 要： | 合成4种11-脱氧甘草次酸3,30双糖链皂苷。以苯甲酰基保护的糖基三氯乙酰亚胺酯为供体,在TMSOTf的催化作用下与11-脱氧甘草次酸C3位羟基和C30位羧基进行偶联,以较好的收率制备得11-脱氧甘草次酸3,30双糖链皂苷(6a,6b,6c,6d)。化合物均未见报道,结构经核磁共振(~1H NMR)确证,均为1,2反式构型糖苷键。
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| 关 键 词： | 11-脱氧甘草次酸 皂苷 糖苷键 合成 |
Synthesis of four 11-deoxoglycyrrhetinic acid 3,30-bisdesmosides |
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| WANG Jun , WEN Weihe , HU Xiaoli , ZHU Yuliang. Synthesis of four 11-deoxoglycyrrhetinic acid 3,30-bisdesmosides[J]. Journal of Nanjing University of Technology, 2012, 34(1): 130-134 |
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| Authors: | WANG Jun WEN Weihe HU Xiaoli ZHU Yuliang |
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| Affiliation: | 1.Department of Forensic Science,Jiangsu Police Institute,Nanjing 210012,China; 2.College of Biotechnology and Pharmaceutical Engineering,Nanjing University of Technology,Nanjing 210009,China) |
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| Abstract: | Four 11-deoxoglycyrrhetinic acid 3,30-bisdesmosides were synthesized.C3-OH and C30-COOH of 11-deoxoglycyrrhetinic acid were coupled as glycosyl-receptors with the benzoyl glycoyl trichloroacetimidates through one-pot glycosylation method on the promotion of TMSOTf to afford 11 -deoxoglycyrrhetinic acid 3,30-bisdesmosides(6a,6b,6c,6d).The structures were characterized by nuclear magnetic resonance spectroscopy(~1H NMR).The result indicatedβglycosidic bond. |
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| Keywords: | 11-deoxoglycyrrhetinic acid saponin glycosidic bond synthesis |
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