| 聚5-羧基吲哚-聚乙交酯可降解导电共聚物的合成与表征 |
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| 引用本文： | 李英,纪小婷,朱英杰,丁彩凤.聚5-羧基吲哚-聚乙交酯可降解导电共聚物的合成与表征[J].南京工业大学学报(自然科学版),2012,34(2):100-105. |
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| 作者姓名： | 李英 纪小婷 朱英杰 丁彩凤 |
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| 作者单位： | 1. 南京工业大学生物与制药工程学院,江苏南京210009;青岛科技大学化学与分子工程学院生态化工教育部重点实验室,山东青岛266042
2. 青岛科技大学化学与分子工程学院生态化工教育部重点实验室,山东青岛,266042 |
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| 基金项目： | 山东省教育厅科技计划资助项目(J09LB04) |
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| 摘 要： | 以N,N'-二环己基碳化二亚胺(DCC)为脱水剂、4-二甲氨基吡啶(DMAP)为催化剂,通过低温缩聚法合成可生物降解并导电的聚5-羧基吲哚(PICA)与聚乙交酯(PGA)的共聚物.合成的产物采用红外光谱仪(FT- IR)、核磁共振氢谱仪(1H NMR)、质谱仪(MS)进行表征.结果表明:产物经25 d降解了41.7％,测得掺杂的共聚物电导率为9.1×10-4 S/cm.将乳仓鼠肾细胞(BHK21)黏附于合成的齐聚物膜上,细胞增殖生长效果明显.
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| 关 键 词： | 聚5-羧基吲哚 聚乙交酯 导电聚合物 降解作用 生物相容性 |
Synthesis and characterization of electroactive oligomer of poly ( indole-5-carboxylic acid ) -polyglycolide |
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| LI Ying
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JI Xiaoting
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ZHU Yingjie
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DING Caifeng.Synthesis and characterization of electroactive oligomer of poly ( indole-5-carboxylic acid ) -polyglycolide[J].Journal of Nanjing University of Technology,2012,34(2):100-105. |
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| Authors: | LI Ying JI Xiaoting ZHU Yingjie DING Caifeng |
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| Institution: | 1,2(1.College of Biotechnology and Pharmaceutical Engineering,Nanjing University of Technology, Nanjing 210009,China;2.Key Laboratory of Eco-Chemical Engineering,Ministry of Education,College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao 266042,China) |
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| Abstract: | A novel degradable electroactive conducting oligomer of poly(indole-5-carboxylic acid)(PICA) and hydroxyl-capped polyglycolide(PGA) was synthesized by low-temperature polycondensation with N,N′-dicyclohexylcarbodiimide(DCC) as dehydrating agent and 4-dimethylaminopyridine(DMAP) as catalyst.The properties and the morphology of the oligomer were characterized by Fourier transform infrared spectrum(FT-IR),nuclear magnetic resonance spectroscopy(1H NMR) and mass spectrometry(MS).The oligomer degradation reached 41.7% in weight in the first 25 d.The electrical conductivity of the doped oligomer was measured to be 9.1×10-4 S/cm.To investigate the biocompatibility of the oligomer,baby hamster kidney 21 cells(BHK21) were cultured on oligomer film.Results indicated that the oligomer could support BHK21 cell attachment and proliferation. |
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| Keywords: | poly(indole-5-carboxylic acid) polyglycolide conducting polymers degradation biocompatibility |
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