Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate |
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Authors: | G Draetta H Piwnica-Worms D Morrison B Druker T Roberts D Beach |
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Institution: | Cold Spring Harbor Laboratory, New York 11724. |
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Abstract: | cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site of cdc2 tyrosine phosphorylation in vivo is selectively phosphorylated by pp60c-src in vitro. |
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