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The landscape of recombination in African Americans |
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| Authors: | Hinch Anjali G Tandon Arti Patterson Nick Song Yunli Rohland Nadin Palmer Cameron D Chen Gary K Wang Kai Buxbaum Sarah G Akylbekova Ermeg L Aldrich Melinda C Ambrosone Christine B Amos Christopher Bandera Elisa V Berndt Sonja I Bernstein Leslie Blot William J Bock Cathryn H Boerwinkle Eric Cai Qiuyin Caporaso Neil Casey Graham Cupples L Adrienne Deming Sandra L Diver W Ryan Divers Jasmin Fornage Myriam Gillanders Elizabeth M Glessner Joseph Harris Curtis C Hu Jennifer J Ingles Sue A Isaacs William John Esther M Kao W H Linda Keating Brendan Kittles Rick A Kolonel Laurence N Larkin Emma |
| Affiliation: | Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK. |
| Abstract: | Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9 (P?value |
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