The functions of mucosal T cells in containing the indigenous commensal flora of the intestine |
| |
Authors: | A. J. Macpherson M. M. Martinic N. Harris |
| |
Affiliation: | 1.Institute of Experimental Immunology, Universit?tsspital, Schmelzbergstrasse 12, 8091 Zürich (Switzerland), Fax +41 1255 4420, e-mail: amacpher@pathol.uniz.ch,CH |
| |
Abstract: | There is an immense load of non-pathogenic commensal bacteria in the distal small intestine and the colon of mammals. The physical barrier that prevents penetration (translocation) of these organisms into the body is a simple epithelium comprised of the single enterocyte/colonocyte cell layer with its overlying mucus. In this review, we discuss the roles of intestinal T cells in initiating and regulating innate and adaptive mucosal immune responses of the mucosal immune system that avoid or limit penetration of the commensal intestinal bacteria. Received 9 August 2002; accepted 9 September 2002 RID="*" ID="*"Corresponding author. |
| |
Keywords: | . Intraepithelial lymphocyte lamina propria lymphocyte IgA commensal bacteria: macrophage: intestinal mucosa. |
本文献已被 PubMed SpringerLink 等数据库收录! |