The functions of mucosal T cells in containing the indigenous commensal flora of the intestine |
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Authors: | A J Macpherson M M Martinic N Harris |
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Institution: | 1.Institute of Experimental Immunology, Universit?tsspital, Schmelzbergstrasse 12, 8091 Zürich (Switzerland), Fax +41 1255 4420, e-mail: amacpher@pathol.uniz.ch,CH |
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Abstract: | There is an immense load of non-pathogenic commensal bacteria in the distal small intestine and the colon of mammals. The
physical barrier that prevents penetration (translocation) of these organisms into the body is a simple epithelium comprised
of the single enterocyte/colonocyte cell layer with its overlying mucus. In this review, we discuss the roles of intestinal
T cells in initiating and regulating innate and adaptive mucosal immune responses of the mucosal immune system that avoid
or limit penetration of the commensal intestinal bacteria.
Received 9 August 2002; accepted 9 September 2002
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ID="*"Corresponding author. |
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Keywords: | , Intraepithelial lymphocyte, lamina propria lymphocyte, IgA, commensal bacteria: macrophage: intestinal mucosa, |
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