| IMRT治疗计划的多目标优化问题 |
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| 引用本文： | 黄禹,段正澄,朱国力,龚时华. IMRT治疗计划的多目标优化问题[J]. 华中科技大学学报(自然科学版), 2007, 35(3): 83-85 |
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| 作者姓名： | 黄禹 段正澄 朱国力 龚时华 |
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| 作者单位： | 华中科技大学,机械科学与工程学院,湖北,武汉,430074;华中科技大学,机械科学与工程学院,湖北,武汉,430074;华中科技大学,机械科学与工程学院,湖北,武汉,430074;华中科技大学,机械科学与工程学院,湖北,武汉,430074 |
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| 摘 要： | 针对形调强放射治疗(IMRT)治疗计划逆向设计的需要,建立了IMRT治疗计划的多目标优化模型.该模型将病灶和健康组织辐照剂量作为约束条件,以剂量均匀性和健康组织与病灶的剂量梯度差作为目标函数.以该模型为基础,采用遗传算法实现了IMRT治疗计划系统优化.经实例计算,获得的剂量分布和病灶形状相比具有较好适形性,且健康组织剂量和病灶组织剂量有很大差别,治疗增益比高.此外,采用的遗传算法能较快收敛,实例计算证明了该模型的适用性和算法的有效性.
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| 关 键 词： | 适形调强放射治疗 治疗计划 多目标优化 遗传算法 |
| 文章编号： | 1671-4512(2007)03-0083-03 |
| 修稿时间： | 2005-11-17 |
Multi-objective optimization of the treatmet planning for IMRT |
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| Huang Yu,Duan Zhengchen,Zhu Guoli,Gong Shihua. Multi-objective optimization of the treatmet planning for IMRT[J]. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY.NATURE SCIENCE, 2007, 35(3): 83-85 |
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| Authors: | Huang Yu Duan Zhengchen Zhu Guoli Gong Shihua |
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| Affiliation: | College of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China |
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| Abstract: | Aiming at the inverse design of treatment planning for intensity modulated radiation therapy(IMRT),the multi-objective optimization model for IMRT was discussed.This model aimed at the dose uniformity and dose grads between target and healthy tissue,considering the dose limit of target and healthy tissue.Based on this model,a genetic algorithm was applied to IMRT plan optimization,and an example was also introduced.In this example,the result of dose distributing conforms to the shape of target,and dose grads between target and healthy tissue are large enough.Moreover the genetic algorithm applied to this model has good convergence property.The result of calculation proves the applicability and validity of the model and the algorithm. |
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| Keywords: | intensity modulated radiation therapy treatment planning multi-objective optimization genetic algorithm |
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