| 表面活性剂对PLA-NPs稳定性和体外释药的影响 |
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| 引用本文： | 郭国宁,刘卫,杨祥良,徐辉碧.表面活性剂对PLA-NPs稳定性和体外释药的影响[J].华中科技大学学报(自然科学版),2007,35(10):112-115. |
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| 作者姓名： | 郭国宁 刘卫 杨祥良 徐辉碧 |
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| 作者单位： | 华中科技大学,生命科学与技术学院,湖北,武汉,430074 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 采用自乳化溶剂挥发法制备了不同性质表面活性剂修饰的聚乳酸纳米粒(PLA-NPs),测定其粒径和zeta电位变化,比较了不同性质表面活性剂修饰的PLA-NPs的稳定性;以5-氨基荧光素(5-AF)为模型药物,研究了4种不同性质表面活性剂修饰的PLA-NPs在pH值为7.4磷酸盐缓冲溶液(PBS)中的药物释放行为.结果表明:PLA-NPs的稳定性与表面活性剂性质密切相关;SDS,Poloxamer 188和BSA修饰的PLA-NPs具有相似的体外药物释放规律,其药物释放曲线呈现明显突释效应;CTAB修饰的PLA-NPs则呈缓慢持续释放,且药物释放量与时间呈线性关系.表面活性剂性质对PLA-NPs稳定性和体外药物释放行为均产生影响.
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| 关 键 词： | 聚乳酸纳米粒 表面活性剂 稳定性 体外药物释放 表面活性剂 稳定性 体外释药 影响 in vitro drug release stability surfactants 线性关系 时间 释放量 持续释放 CTAB 突释效应 释放曲线 药物释放规律 相似 Poloxamer 相关 结果 |
| 文章编号： | 1671-4512（2007）10-0112-04 |
| 修稿时间： | 2006-09-26 |
The effects of surfactants on the stability and drug release of PLA-NPs in vitro |
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| Guo Guoning,Liu Wei,Yang Xiangliang,Xu Huibi.The effects of surfactants on the stability and drug release of PLA-NPs in vitro[J].JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY.NATURE SCIENCE,2007,35(10):112-115. |
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| Authors: | Guo Guoning Liu Wei Yang Xiangliang Xu Huibi |
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| Institution: | College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China |
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| Abstract: | Poly(D,L-lactide) nanoparticles(PLA-NPs) modified with different surfactants was prepared by the spontaneous emulsification solvent diffusion method,whose particle size and the zeta potential was measured at different time points and whose stability was compared.The effects of different surfactants on drug release in vitro were investigated by using 5-aminofluorescein as model drug.The stability of PLA-NPs was closely relative to the properties of surfactants.PLA-NPs modified with SDS,Poloxamer 188 and BSA had similar drug release in vitro,which showed burst release profile.However,PLA-NPs modified with CTAB had different release profile that was followed by a constant release.Different surfactants have different effects on the stability and release of PLA-NPs in vitro. |
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| Keywords: | poly(D L-lactide) nanoparticles(PLA-NPs) surfactants stability drug release in vitro |
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