Possible involvement of calmodulin in apical constriction of neuroepithelial cells and elevation of neural folds in the chick |
| |
| Authors: | H Lee R G Nagele |
| |
| Institution: | (1) Department of Biology, Rutgers University, 08102 Camden, New Jersey, USA;(2) Department of Pediatrics, UMDNJ-School of Osteopathic Medicine, 08103 Camden, New Jersey, USA |
| |
| Abstract: | Summary Chlorpromazine and trifluoperazine HCl, antipsychotic drugs known to bind to calmodulin, reversibly inhibited elevation of neural folds by interfering with the contractile activity of apical microfilament bundles in developing chick neuroepithelial cells.We wish to thank C. Hess for her technical assistance. This study was supported in part by grants from the Busch Fund (Rutgers University), UMDNJ Foundation and Kapnek Fund. |
| |
| Keywords: | Chick embryo neurulation microfilaments calmodulin phenothiazine antipsychotic drugs |
| 本文献已被 SpringerLink 等数据库收录！ |
|
