Age-dependent changes of rat liver plasma membrane composition |
| |
Authors: | A Spinedi S Rufini P Luly |
| |
Institution: | (1) Department of Biology, 2nd University of Rome Tor Vergata , via O. Raimondo, I-00173 Rome, (Italy) |
| |
Abstract: | Summary The chemical composition of liver plasma membrane was studied in Wistar rats aged between 3 and 24 months. Results obtained indicate a significant age-dependent positive correlation of both the protein:phospholipid and cholesterol:phospholipid ratios, whereas the protein:cholesterol ratio seems to remain unaffected. Phospholipid analysis of liver plasma membrane reveals that only the phosphatidylcholine content has a significant negative correlation with age; all other phospholipid species remain basically unchanged.Supported by a grant of the Italian National Research Council, Project Preventive and Rehabilitative Medicine , Subproject Mechanisms of Aging . |
| |
Keywords: | Liver plasma membrane aging phospholipids cholesterol |
本文献已被 SpringerLink 等数据库收录! |