Structure and stereochemistry of brianolide, a new antiinflammatory diterpenoid from the Okinawan gorgonian Briareum sp. |
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| Authors: | J Kobayashi J F Cheng H Nakamura Y Ohizumi Y Tomotake T Matsuzaki K J Grace R S Jacobs Y Kato L S Brinen |
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| Institution: | Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. |
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| Abstract: | Brianolide (1), a new antiinflammatory diterpenoid of the briarein class, possessing a beta substituent at C-12 (R), has been isolated from the Okinawan gorgonian Briareum sp. Its structure has been established from spectral data in conjunction with a single crystal X-ray analysis. |
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