Studies of bone matrix molecules give us insights into bone remodelling

Bone is one of the most dynamic tissues, with constant remodelling and repair of minor defects during the whole life cycle. These processes have key roles in replacing fatigued, non-functional tissue with fresh tissue which has the proper mechanical properties. In this process, a balance between breakdown of less functional tissue and new tissue production is a prerequisite for tissue integrity and function. One of the major health problems in the elderly, i.e. osteoporosis and ensuing bone fracture, is caused by an imbalance between breakdown and synthesis in this continuous bone remodelling. Thus the study of cellular and molecular events governing the relevant processes is a prerequisite for understanding mechanisms and for future efficient therapeutical intervention.